Comparison of The Effects of Propolis and Royal Jelly Compared to Atorvastatin in Lowering The Levels of Lipids and Some Antioxidants in The Serum of Male Hyperlipidemic Rats

Ahmed Ali  Ahmed; Qays Assi Ahmed; Sahib Jumaah Abdulrahman

doi:10.17605/cajmns.v6i3.2831

Ahmed Ali Ahmed University of Kirkuk, Iraq
Qays Assi Ahmed University of Kirkuk, Iraq
Sahib Jumaah Abdulrahman University of Kirkuk, Iraq

DOI: https://doi.org/10.17605/cajmns.v6i3.2831

Keywords: Propolis, Royal Jelly, Catalase, Malondialdehyde, Hyperlipidemia

Abstract

Hyperlipidemia negatively affects blood lipid and antioxidant levels due to the formation of free radicals. The accumulation of lipids, especially in endothelial structures, leads to the release of inflammatory substances, where the accumulation of triglycerides and oxidized cholesterol leads to increased oxidation, which exacerbates the production of free radicals. Free radicals are unstable molecules caused by metabolic reactions or external factors such as smoking and pollution. Their unbalanced increase leads to cell damage, and this damage affects fat cells and makes them more susceptible to hypertrophy and excessive fat storage. This study investigated the effect of propolis and royal jelly on hyperlipidemia and antioxidants due to the phenolic, sterolic, and antioxidant components of the two substances and compared them with atorvastatin, one of the most popular statins. 30 rats were used, divided into 6 groups, fed a high-fat diet, then treated with the above substances, and lipid levels and concentrations of some antioxidants were measured. After serological analysis, a clear effect of propolis and royal jelly on cholesterol and antioxidant levels was observed. Due to their effectiveness and ingredients. The research shows the importance of using natural products instead of medications in treating diseases. The research shows the importance of locally produced materials and their effective role in treating high fat. The research is also the first of its kind to study the synergistic effect of the alcoholic extract of propolis and royal jelly together.

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