Clinical and Immunological Characteristics of The Course of Community-Acquired Pneumonia in Children

U.R.  Fayziyeva

doi:10.17605/cajmns.v6i3.2773

U.R. Fayziyeva Termez branch of Tashkent Medical Academy

DOI: https://doi.org/10.17605/cajmns.v6i3.2773

Keywords: Children, Community-Acquired Pneumonia, Interleukins, Cytokines, Interferons, Immunology, Uzbekistan, Inflammation

Abstract

Community-acquired pneumonia (CAP) continues to be a major health challenge and a leading cause of child mortality globally, particularly in ecologically unfavorable regions. In Uzbekistan, environmental, socio-cultural, and infrastructural disparities exacerbate CAP prevalence among children, while viral-bacterial shifts post-COVID-19 complicate its clinical course. Despite advancements in diagnosis and treatment, limited regional studies have explored cytokine profiles in young children with CAP, particularly in the Uzbek population of the Surkhandarya region, where genotyping and immune response data remain insufficient. This study aims to characterize the clinical features of CAP in children and investigate serum levels of IL-1β, IL-4, TNF-α, and interferons (α, β, γ), identifying their diagnostic and prognostic value.The study of 50 children revealed a predominance of acute clinical symptoms such as hyperthermia, dyspnea, and severe intoxication, accompanied by distinct cytokine imbalances, notably elevated IL-1β and IL-4 levels and significant shifts in interferon profiles, indicating a strong inflammatory response. This is the first immunogenetic investigation of pediatric CAP in the Surkhandarya region, highlighting the relationship between cytokine levels and disease severity, and offering a molecular perspective on the pathogenesis of CAP. Findings suggest cytokine profiling can inform early diagnostics, prognostics, and individualized immunomodulatory therapies, supporting improved clinical outcomes and rational antibiotic use in pediatric CAP.

References

A. L. Zaplatnikov, «Respiratory mycoplasmosis in pediatrician’s practice», Pract. J., вып. 1, сс. 157–161, 2016.

K. Messacar, R. E. Baker, S. W. Park, и others, «Preparing for uncertainty: endemic pediatric viral illnesses after COVID-19 pandemic disruption», Lancet, вып. 400(10364), сс. 1663–1665, 2022, doi: 10.1016/S0140-6736(22)01277-6.

A. G. Chuchalin, «Pneumonia: a current problem of medicine in the 21st century», Ther. Arch., т. 88, вып. 3, сс. 4–12, 2016.

Yu. L. Mizernitsky, «Macrolides in modern therapy of community-acquired pneumonia in children», Med. Counc., вып. 18, сс. 80–85, 2020.

I. A. Karimjonov и U. R. Fayzieva, «Genetic Predisposition To Out-Of-Hospital Pneumonia In Children: A Modern Interpretation Of The Problem», Am. J. Med. Sci. Pharm. Res., т. 3, вып. 05, сс. 51–57, doi: 10.37547/TAJMSPR/Volume03Issue0509.

R. Jia, J. Yang, Y. Cui, и others, «Gene expression analysis for pneumonia caused by Gram-positive bacterial infection», Exp. Ther. Med., т. 15, вып. 4, сс. 3989–3996, 2018, doi: 10.3892/etm.2018.5904.

N. A. Geppe и V. K. Tatochenko, Community-acquired pneumonia in children. Clinical guidelines. Moscow: MedKom-Pro, 2020.

U. R. Fayziyeva, «Community-acquired pneumonia in children: a modern view», New Day Med., вып. 3, сс. 245–249, 2020.

V. K. Tatochenko, «Community-acquired pneumonia in children – problems and solutions», Ros Est Perinatol Pediatr, вып. 66–1, сс. 9–21, 2021, doi: 10.21508/1027–4065–2021–66–1–9–21.

P. M. Meyer Sauteur, «Childhood community-acquired pneumonia», Eur. J. Pediatr., т. 183, вып. 3, сс. 1129–1136, 2024, doi: 10.1007/s00431-023-05366-6.

Ya. I. Zhakov, «Antibacterial therapy of community-acquired pneumonia in the pediatric area», в Pediatric pulmonology: problems and solutions, Yu. L. Mizernitsky, Ред., Moscow: MEDPRAKTIKA-M, 2017, сс. 120–121.

M. Ciofi Degli Atti, C. Rizzo, C. D’Amore, и others, «Acute respiratory infection emergency access in a tertiary care children hospital in Italy, prior and after the SARS-CoV-2 emergence», Influenza Other Respir. Viruses, т. 17, вып. 3, с. 13102, 2023, doi: 10.1111/irv.13102.

J.-M. Dayer, F. Oliviero, и L. Punzi, «A Brief History of IL-1 and IL-1 Ra in Rheumatology», Front. Pharmacol., т. 8, 2017, doi: 10.3389/fphar.2017.00293.

I. J. Haq, A. C. Battersby, K. Eastham, и M. McKean, «Community acquired pneumonia in children», Bmj, т. 356, 2017, Просмотрено: 3 апрель 2025 г. [Онлайн]. Доступно на: https://www.bmj.com/content/356/bmj.J686.abstract

Z. V. Rueda и др., «Etiology and the challenge of diagnostic testing of community-acquired pneumonia in children and adolescents», BMC Pediatr., т. 22, вып. 1, с. 169, мар. 2022, doi: 10.1186/s12887-022-03235-z.