Glutathione S Transferase Impact on Acute Myeloid Leukemia Recurrence
Keywords:
Acute myeloid leukemia, Glutathione S transferase, Polymerase chain reaction
Abstract
The superfamily of glutathione S transferase enzymes (GSTs) were collected from several enzymes by an important polymorphic functional variance signal. GSTs remove toxins that may cause genetic mutations, then toxic and interacting with DNA, and which include the metabolites of many chemotherapy administrators, which some suspects are human carcinogens. To report how changes in human goods and services tax affect enzyme expressions in carcinogenic susceptibility, diagnosis, then treatment. This study included 60 patients with AML, as well as 50 healthy volunteers, with genotyping of GSTP 1, GSTM 1, and then GSTT 1 polymorphic gene were utilizing polymerase chain reaction and restriction polymorphic fraction (PCR - RFLP), then conventional PCR. The GSTP 1313 A→G polymorphism (GSTP1 Ile105Val), that the wild genotype (AA) among the control subjects was significantly higher (P value = 0.0377) it was established, while the incidence of the mutant genotype (AG) then was the mutant G allele (GG + AG) significantly elevated amid patients (P-value = 0.050, P-value = 0.026, in contrast). Targeting GSTM1 and then GSTT1gene, highlighted a significantly higher incidence among patients with respect to homozygous gene removal (P-value = 0.001). Creating the action of antioxidant enzymes may be the way cancer cells protect themselves in contrast to increased oxidative stress.
References
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WHO Organization, "Cancer [online]," World Health Organization, 2018. Available: http://www.who.int/news-room/Fact-sheets/Details/Cancer
F. Islami, L. A. Torre, and A. Jemal, "Global Trends of Lung Cancer Mortality and Smoking Prevalence," Translational Lung Cancer Research, vol. 4, no. 4, pp. 327-338, Aug. 2015.
UK CR., "Worldwide Cancer Statistics," Cancer Research UK, 2012. Available: https: //www.cancerresearchuk.org/health-professional/cancer-Statistics/worldwide-cancer#collapseFour
J. M. Samet, E. Avila-Tang, P. Boffetta, L. M. Hannan, S. Olivo-Marston, M. J. Thun, and C. M. Rudin, "Lung Cancer in Never Smokers: Clinical Epidemiology and Environmental Risk Factors," Clinical Cancer Research, vol. 15, no. 18, pp. 5626–5645, Sep. 2009, doi: https://doi.org/10.1158/1078-0432.ccr-09-0376
C. Clément-Duchêne, J.-M. Vignaud, A. Stoufflet, O. Bertrand, A. Gislard, L. Thiberville, G. Grosdidier, Y. Martinet, J. Benichou, P. Hainaut, and C. Paris, "Characteristics of Never Smoker Lung Cancer Including Environmental and Occupational Risk Factors," Lung Cancer, vol. 67, no. 2, pp. 144–150, Feb. 2010, doi: https://doi.org/10.1016/j.lungcan.2009.04.005
J. A. García-Lavandeira, A. Ruano-Ravina, and J. M. Barros-Dios, "Alcohol Consumption and Lung Cancer Risk in Never Smokers," Gaceta Sanitaria, vol. 30, no. 4, pp. 311–317, Jul. 2016, doi: https://doi.org/10.1016/j.gaceta.2016.03.017
J. Hukkanen, O. Pelkonen, J. Hakkola, and H. Raunio, "Expression and Regulation of Xenobi-otic-Metabolizing Cytochrome P450 (CYP) Enzymes in Human Lung," Critical Reviews in Toxicology, vol. 32, no. 5, pp. 391–411, Jan. 2002, doi: https://doi.org/10.1080/20024091064273
X.-Y. Jiang, F.-H. Chang, T.-Y. Bai, X.-L. Lv, M.-J. Wang, and G. Wang, "Susceptibility of Lung Cancer With Polymorphisms of CYP1A1, GSTM1, GSTM3, GSTT1 and GSTP1 Genotypes in the Population of Inner Mongolia Region," Asian Pacific Journal of Cancer Prevention, vol. 15, no. 13, pp. 5207–5214, Jul. 2014, doi: https://doi.org/10.7314/apjcp.2014.15.13.5207
P. Mota, H. C. Silva, M. J. Soares, A. Pego, C. R. Cordeiro, and F. J. Regateiro, "Genetic Polymorphisms of Phase I and Phase II Metabolic Enzymes as Modulators of Lung Cancer Susceptibility," Journal of Cancer Research and Clinical Oncology, vol. 141, no. 5, pp. 851–860, Nov. 2014, doi: https://doi.org/10.1007/s00432-014-1868-z
J. D. Hayes, J. U. Flanagan, and I. R. Jowsey, "Glutathione Transferases," Annual Review of Pharmacology and Toxicology, vol. 45, no. 1, pp. 51–88, Sep. 2005, doi: https://doi.org/10.1146/annurev.pharmtox.45.120403.095857
S. Tsuchida and T. Yamada, "Glutathione Transferases☆," in Reference Module in Biomedical Sciences, Elsevier, 2014, doi: https://doi.org/10.1016/b978-0-12-801238-3.04351-8
F. K. Safa, G. Shahsavari, and R. Z. Abyaneh, "Glutathione S-Transferase M1 and T1 Genetic Polymorphisms in Iranian Patients With Glaucoma," Iranian Journal of Basic Medical Sciences, vol. 175, no. 5, pp. 332–336, May 2014.
Z. Almasi, H. Salehiniya, N. Amoori, and M. Enayatrad, "Epidemiology Characteristics and Trends of Lung Cancer Incidence in Iran," Asian Pacific Journal of Cancer Prevention, vol. 17, no. 2, pp. 557–562, Mar. 2016, doi: https://doi.org/10.7314/apjcp.2016.17.2.557
C. Carlsten, G. S. Sagoo, A. J. Frodsham, W. Burke, and J. P. T. Higgins, "Glutathione S-Transferase M1 (GSTM1) Polymorphisms and Lung Cancer: A Literature-Based Systematic HuGE Review and Me-ta-Analysis," American Journal of Epidemiology, vol. 167, no. 7, pp. 759–774, Feb. 2008, doi: https://doi.org/10.1093/aje/kwm383
C. Clément-Duchêne, J.-M. Vignaud, A. Stoufflet, O. Bertrand, A. Gislard, L. Thiberville, G. Grosdidier, Y. Martinet, J. Benichou, P. Hainaut, and C. Paris, "Characteristics of Never Smoker Lung Cancer Including Environmental and Occupational Risk Factors," Lung Cancer, vol. 67, no. 2, pp. 144–150, Feb. 2010, doi: https://doi.org/10.1016/j.lungcan.2009.04.005
N. N. Chakova, E. P. Mikhalenko, S. N. Polonetskaya, N. V. Chebotareva, Y. E. Demidchik, A. A. Zhilko, O. V. Kvitko, and E. V. Krupnova, "GST Polymorphism and Cytogenetic Changes in Lung Tissues of Lung Cancer Patients," Cytology and Genetics, vol. 43, no. 1, pp. 38–41, Feb. 2009, doi: https://doi.org/10.3103/s0095452709010071
A. Demir, S. Altin, D. Pehlivan, M. Demir, F. Yakar, E. Seyhan, and S. Dincer, "The Role of GSTM1 Gene Polymorphisms in Lung Cancer Development in Turkish Population," Journal of Carcinogenesis, vol. 6, no. 1, pp. 13, 2007, doi: https://doi.org/10.1186/1477-3163-6-13
S. Garte, E. Taioli, T. Popov, I. Kalina, R. Sram, and P. Farmer, "Role of GSTT1 Deletion in DNA Oxidative Damage by Exposure to Polycyclic Aromatic Hydrocarbons in Humans," International Journal of Cancer, vol. 120, no. 11, pp. 2499–2503, Mar. 2007, doi: https://doi.org/10.1002/ijc.22477
Y. Zhao, B. Wang, K. Hu, J. Wang, S. Lu, Y. Zhang, W. Lu, E. Zhao, and L. Yuan, "Glutathione S-Transferase Θ1 Polymorphism Contributes to Lung Cancer Susceptibility: A Meta-Analysis of 26 Case-Control Studies," Oncology Letters, vol. 9, no. 4, pp. 1947–1953, Feb. 2015, doi: https://doi.org/10.3892/ol.2015.2948
L. Fontana, L. Delort, L. Joumard, N. Rabiau, R. Bosviel, S. Satih, A. Kwiatkowski, V. Bignon, and F. Ber-nard-Gallon, "Genetic Polymorphisms in GSTT1, GSTM1, and GSTP1 and the Risk of Hormone-Dependent Cancer," Anticancer Research, vol. 29, no. 11, pp. 4769–4774, Nov. 2009.
Y. Gao, F. Gao, T.-T. Hu, G. Li, and Y.-X. Sui, "Combined effects of glutathione S-transferase M1 and T1 polymorphisms on risk of lung cancer: evidence from a meta-analysis," Oncotarget, vol. 8, no. 17, pp. 28135–28143, Mar. 2017, doi: https://doi.org/10.18632/oncotarget.15943
S. Garte, E. Taioli, T. Popov, I. Kalina, R. Sram, and P. Farmer, "Role of GSTT1 deletion in DNA oxidative damage by exposure to polycyclic aromatic hydrocarbons in humans," International Journal of Cancer, vol. 120, no. 11, pp. 2499–2503, Mar. 2007, doi: https://doi.org/10.1002/ijc.22477
J. D. Hayes, J. U. Flanagan, and I. R. Jowsey, "Glutathione Transferases," Annual Review of Pharmacology and Toxicology, vol. 45, no. 1, pp. 51–88, Sep. 2005, doi: https://doi.org/10.1146/annurev.pharmtox.45.120403.095857
R. Hezova, J. Bienertova-Vasku, M. Sachlova, V. Brezkova, A. Vasku, M. Svoboda, L. Radová, I. Kiss, R. Vyzula, and O. Slaby, "Common polymorphisms in GSTM1, GSTT1, GSTP1, GSTA1 and susceptibility to colorectal cancer in the Central European population," European Journal of Medical Research, vol. 17, no. 1, Jun. 2012, doi: https://doi.org/10.1186/2047-783x-17-17
H. N. Honma, E. M. De Capitani, M. W. Perroud, A. S. Barbeiro, I. F. C. Toro, D. B. Costa, C. S. P. Lima, and L. Zambon, "Influence of p53 codon 72 exon 4, GSTM1, GSTT1 and GSTP1*B polymorphisms in lung cancer risk in a Brazilian population," Lung Cancer, vol. 61, no. 2, pp. 152–162, Aug. 2008, doi: https://doi.org/10.1016/j.lungcan.2007.12.014
G. Adibhesami, G. R. Shahsavari, A. Amiri, A. N. Emami Razavi, M. Shamaei, and M. Birjandi, "Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) polymorphisms and lung cancer risk among a select group of Iranian people," Asian Pacific Journal of Cancer Prevention: APJCP, vol. 19, no. 10, pp. 2921–2927, Oct. 2018.
Published
2024-06-21
How to Cite
Mahdi, A. G., & Yousif, A. F. (2024). Glutathione S Transferase Impact on Acute Myeloid Leukemia Recurrence. Central Asian Journal of Medical and Natural Science, 5(3), 606-613. Retrieved from https://www.cajmns.centralasianstudies.org/index.php/CAJMNS/article/view/2488
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Copyright (c) 2024 Abeer Ghassan Mahdi, Abdullah Fakhir Yousif
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