Comparing Bupivacaine and Fentanyl Doses in Spinal Anesthesia for Cesareans
Keywords:
fentanyl, bupivacaine, spinal anesthesia, cesarean section, anesthesia optimization
Abstract
This study evaluated the effectiveness of various fentanyl doses combined with bupivacaine for elective cesarean sections under spinal anesthesia. One hundred twenty expectant mothers were randomly assigned to four groups based on fentanyl doses: Group I (control) received 10 mg of 0.5% hyperbaric bupivacaine, while Groups II, III, and IV received additional 10 µg, 7.5 µg, and 15 µg of fentanyl, respectively. When further anesthesia was required, an epidural catheter was used. The study assessed anesthetic blockade characteristics, maternal and neonatal adverse effects, and maternal side effects. Statistical analysis employed Fisher's exact and chi-square tests, with significance set at p < 0.05. The findings provide insights into optimizing fentanyl doses in spinal anesthesia for cesarean sections, enhancing maternal and neonatal safety and comfort.
References
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N. J. B. A. et al. Hunt CO, "Perioperative Analgesia with Subarachnoid Fentanyl Bupivacaine for Cesarean Delivery," Anesthesiology, vol. 71, pp. 535-40, 1989.
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Y. A. K. N. et al. Sanli S, "Effects of Hyperbaric Spinal Ropivacaine for Caesarean Section: With or Without Fentanyl," Eur J Anaesthesiol, vol. 22, pp. 457-61, 2005.
B. F. H. E. et al. Braga Ade F, "Association of Lipophilic Opioids and Hyperbaric Bupivacaine in Spinal Anesthesia for Elective Cesarean Section," Acta Cir Bras, vol. 29, pp. 752-8, 2014.
T. C. P. A. et al. Gauchan S, "Effects of Intrathecal Fentanyl as an Adjunct to Hyperbaric Bupivacaine in Spinal Anesthesia for Elective Caesarean Section," Nepal Med Coll J, vol. 16, pp. 5-8, 2014.
K. S. U. M. et al. Karaman S, "The Effects of Sufentanyl or Morphine Added to Hyperbaric Bupivacaine in Spinal Anaesthesia for Caesarean Section," Eur J Anaesthesiol, vol. 23, pp. 285-91, 2006.
G. I. U. M. et al. Karaman S, "The Effects of Morphine and Fentanyl Alone or in Combination Added to Intrathecal Bupivacaine in Spinal Anesthesia for Cesarean Section," AGRI, vol. 23, pp. 57-63, 2011.
J. I. J. H. et al. Dahl JB, "Intraoperative and Postoperative Analgesic Efficacy and Adverse Effects of Intrathecal Opioids in Patients Undergoing Cesarean Section with Spinal Anesthesia," Anesthesiology, vol. 91, pp. 1919-27, 1999.
G. V. M. R. et al. Jain K, "Effect of Varying Doses of Fentanyl with Low Dose Spinal Bupivacaine for Caesarean Delivery in Patients with Pregnancy-Induced Hypertension," Int J Obstet Anesth, vol. 13, pp. 215-20, 2004.
R. J. M. S. et al. Viscomi CM, "Analgesic Efficacy and Side Effects of Subarachnoid Sufentanyl-Bupivacaine Administered to Women in Advanced Labor," Reg Anesth, vol. 21, pp. 424-9, 1999.
S. S. M. et al. Ali MA, "A Double-Blind Randomized Control Trial to Compare the Effect of Varying Doses of Intrathecal Fentanyl on Clinical Efficacy and Side Effects in Parturients Undergoing Caesarean Section," J Anaesthesiol Clin Pharmacol, vol. 34, pp. 221-6, 2018.
F. J. B. F. et al. Braga AFA, "Intrathecal Fentanyl with Small-Dose Dilute Bupivacaine: Better Anesthesia Without Prolonging Recovery," Rev Bras Aensthesiol, vol. 60, pp. 121-9, 2010.
N. J. B. A. et al. Hunt CO, "Perioperative Analgesia with Subarachnoid Fentanyl Bupivacaine for Cesarean Delivery," Anesthesiology, vol. 71, pp. 535-40, 1989.
M. D. Uppal V, "Strategies for Prevention of Spinal-Associated Hypotension During Cesarean Delivery: Are We Paying Attention," Can J Anaesth, vol. 64, pp. 991-6, 2017.
S. S. L. S. et al. Chu CC, "The Effect of Intrathecal Bupivacaine with Combined Fentanyl in Cesarean Section," Acta Anaesthesiol Sin, vol. 33, pp. 149-54, 1995.
S. E. L. H. et al. Ben-David B, "Intrathecal Fentanyl with Small-Dose Dilute Bupivacaine: Better Anesthesia Without Prolonging Recovery," Anesth Analg, vol. 85, pp. 560-5, 1997.
H. C. J. J. et al. Dahlgren G, "Intrathecal Sufentanyl, Fentanyl, or Placebo Added to Bupivacaine for Cesarean Section," Anesth Analg, vol. 85, 1997.
C. K. L. J. et al. Lee JH, "Comparison of Fentanyl and Sufentanyl Added to 0.5% Hyperbaric Bupivacaine for Spinal Anesthesia in Patients Undergoing Cesarean Section," Korean J Anesthesiol, vol. 60, 2011.
A. P. Z. R. et al. Sibilla C, "Perioperative Analgesia for Caesarean Section: Comparison of Intrathecal Morphine and Fentanyl Alone or in Combination," Int J Obstet Anesth, vol. 6, pp. 43-8, 1997.
Y. A. K. N. et al. Sanli S, "Effects of Hyperbaric Spinal Ropivacaine for Caesarean Section: With or Without Fentanyl," Eur J Anaesthesiol, vol. 22, pp. 457-61, 2005.
B. F. H. E. et al. Braga Ade F, "Association of Lipophilic Opioids and Hyperbaric Bupivacaine in Spinal Anesthesia for Elective Cesarean Section," Acta Cir Bras, vol. 29, pp. 752-8, 2014.
T. C. P. A. et al. Gauchan S, "Effects of Intrathecal Fentanyl as an Adjunct to Hyperbaric Bupivacaine in Spinal Anesthesia for Elective Caesarean Section," Nepal Med Coll J, vol. 16, pp. 5-8, 2014.
K. S. U. M. et al. Karaman S, "The Effects of Sufentanyl or Morphine Added to Hyperbaric Bupivacaine in Spinal Anaesthesia for Caesarean Section," Eur J Anaesthesiol, vol. 23, pp. 285-91, 2006.
G. I. U. M. et al. Karaman S, "The Effects of Morphine and Fentanyl Alone or in Combination Added to Intrathecal Bupivacaine in Spinal Anesthesia for Cesarean Section," AGRI, vol. 23, pp. 57-63, 2011.
J. I. J. H. et al. Dahl JB, "Intraoperative and Postoperative Analgesic Efficacy and Adverse Effects of Intrathecal Opioids in Patients Undergoing Cesarean Section with Spinal Anesthesia," Anesthesiology, vol. 91, pp. 1919-27, 1999.
G. V. M. R. et al. Jain K, "Effect of Varying Doses of Fentanyl with Low Dose Spinal Bupivacaine for Caesarean Delivery in Patients with Pregnancy-Induced Hypertension," Int J Obstet Anesth, vol. 13, pp. 215-20, 2004.
R. J. M. S. et al. Viscomi CM, "Analgesic Efficacy and Side Effects of Subarachnoid Sufentanyl-Bupivacaine Administered to Women in Advanced Labor," Reg Anesth, vol. 21, pp. 424-9, 1999.
S. S. M. et al. Ali MA, "A Double-Blind Randomized Control Trial to Compare the Effect of Varying Doses of Intrathecal Fentanyl on Clinical Efficacy and Side Effects in Parturients Undergoing Caesarean Section," J Anaesthesiol Clin Pharmacol, vol. 34, pp. 221-6, 2018.
F. J. B. F. et al. Braga AFA, "Intrathecal Fentanyl with Small-Dose Dilute Bupivacaine: Better Anesthesia Without Prolonging Recovery," Rev Bras Aensthesiol, vol. 60, pp. 121-9, 2010.
Published
2024-05-31
How to Cite
Hasan, A. M., Taha, M. Q., & Almuslehi, N. H. O. (2024). Comparing Bupivacaine and Fentanyl Doses in Spinal Anesthesia for Cesareans. Central Asian Journal of Medical and Natural Science, 5(3), 429-440. Retrieved from https://www.cajmns.centralasianstudies.org/index.php/CAJMNS/article/view/2463
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Articles
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