New Thiadiazole Derivative Shows Promising Bioactivity with Transition Metals in Rats
Keywords:
Thiadiazole, Characterization, Liver Enzymes, Magnetic Susceptibility, Blood Parameters
Abstract
This study explores the synthesis and characterization of new transition metal complexes using 1,3,4-thiadiazole-2-amino,5-thiol derivatives as novel ligands, with CrCl3.6H2O, FeCl3, and NiCl2.6H2O. Characterization was achieved through magnetic susceptibility, molar conductance, 1H NMR, IR spectroscopy, mass spectrometry, and elemental microanalysis (C.H.N.). The biological effects were evaluated on rats, focusing on hemoglobin (Hb), packed cell volume (PCV), liver enzymes, urea, and creatinine levels. Results indicated that the thiadiazole derivative increased Hb and PCV, while reducing liver enzymes, urea, and creatinine levels, suggesting no toxic effect and potential anti-inflammatory properties. Further studies are recommended to investigate potential anti-cancer, anti-bacterial, and anti-fungal activities. This research fills a knowledge gap by providing new insights into the bioactivity and structural characteristics of thiadiazole metal complexes.
References
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[2] T. Karabasanagouda, A. V. Adhikari, R. Dhanwad, and G. Parameshwarappa, "Synthesis of Some New 2-(4-Alkylthiophenoxy)-4-Substituted-1,3-Thiazoles as Possible Anti-Inflammatory and Antimicrobial Agents," Indian J. Chem. Sect. B Org. Incl. Med., vol. 47, no. 1, p. 144, 2008.
[3] M. D. Mullican, M. W. Wilson, D. T. Conner, C. R. Kostlan, D. J. Schrier, and R. D. Dyer, "Design of 5-(3,5-Di-Tert-Butyl-4-Hydroxyphenyl)-1,3,4-Thiadiazoles, -1,3,4-Oxadiazoles, and -1,2,4-Triazoles as Orally Active, Nonulcerogenic Antiinflammatory Agents," J. Med. Chem., vol. 36, no. 8, pp. 1090–1099, 1993.
[4] A. Foroumadi, A. Asadipour, M. Mirzaei, J. Karimi, and S. Emami, "Antituberculosis Agents. V. Synthesis, Evaluation of In Vitro Antituberculosis Activity and Cytotoxicity of Some 2-(5-Nitro-2-Furyl)-1,3,4-Thiadiazole Derivatives," Farm., vol. 57, no. 9, pp. 765–769, 2002.
[5] N. H. Parmar and K. C. Umrigar, "Synthesis of 1,3,4-Thiadiazole Derivatives and Its Biological Activity," J. Chem. Pharm. Res., vol. 9, no. 6, pp. 202–214, 2017.
[6] N. A. Abdel-Riheem, N. M. Rateb, A. A. Al-Atoom, and A. O. Abdelhamid, "1,3,4-Thia- and Selenadiazole and 1,2,4-Triazolo[4,3-a]pyrimidine Derivatives from Hydrazonoyl Halides," Heteroat. Chem. An Int. J. Main Gr. Elem., vol. 14, no. 5, pp. 421–426, 2003.
[7] N. Siddiqui, P. Ahuja, W. Ahsan, S. N. Pandeya, and M. S. Alam, "Thiadiazoles: Progress Report on Biological Activities," J. Chem. Pharm. Res., vol. 1, no. 1, pp. 19–30, 2009.
[8] A. T. Mavrova, D. Wesselinova, Y. A. Tsenov, and P. Denkova, "Synthesis, Cytotoxicity and Effects of Some 1,2,4-Triazole and 1,3,4-Thiadiazole Derivatives on Immunocompetent Cells," Eur. J. Med. Chem., vol. 44, no. 1, pp. 63–69, 2009.
[9] R. A. Aljabery and I. Flifel, "Synthesis, Characterization, Antimicrobial Studies of New 5-[(2E)-2-{(2Z)-2-[2-(5-Sulfanyl-1,3,4-Thiadiazol-2-Yl) Hydrazinylidene] Ethylidene} Hydrazinyl]-1,3,4-Thiadiazole-2-Thiol and Their Transition Metal Complexes," Int. J. Pharm. Res., vol. 10, no. 4, 2018.
[10] A. H. Gatea, "Synthesis, Characterization, Antimicrobial Studies of New 2,2'-{(1Z,2Z) Ethane-1,2 Diylidenebis [(2Z) Hydrazin-1-Yl-2-Ylidene-1,3,4-Oxadiazole-5,2-Diyl]} Diphenol and Their Transition Metal Complexes," J. Glob. Pharm. Technol., vol. 10, no. 3, pp. 102–111, 2018.
[11] T. T. Al-Nahary, "Synthesis and Characterization of Metal Complexes of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Ru(III), Rh(III) and Pd(II) with Derivatives of 1,3,4-Thiadiazole-2,5-Dithiol as New Ligands," J. Saudi Chem. Soc., vol. 13, no. 3, pp. 253–257, 2009.
[12] A. Varvaresou, A. Tsantili-Kakoulidou, T. Siatra-Papastaikoudi, and E. Tiligada, "Synthesis and Biological Evaluation of Indole Containing Derivatives of Thiosemicarbazide and Their Cyclic 1,2,4-Triazole and 1,3,4-Thiadiazole Analogs," Arzneimittelforschung, vol. 50, no. 1, pp. 48–54, 2000.
[13] N. Cesur, S. Birteksöz, and G. Ötük, "Synthesis and Biological Evaluation of Some New Thiosemicarbazide, 4-Thiazolidinone, 1,3,4-Oxadiazole and 1,2,4-Triazole-3-Thione Derivatives Bearing Imidazo[1,2-a]Pyridine Moiety," Acta Pharm. Turcica, vol. 44, pp. 23–41, 2002.
[14] F. J. Baker and R. E. Silvorton, "Introduction to Medical Laboratory Technology," 5th ed., Butterworths, London, UK, 1976, pp. 735.
[15] R. N. Prasad and M. Mathur, "Synthesis Characterization of Cr(III), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) Complexes of 2,12-Dimethyl-3,13-Di-n-Propyl-l,4,11,14-Tetraazacycloeicosa-1,13,11,13-Tetraene," J. Serbian Chem. Soc., vol. 67, no. 12, pp. 825–832, 2002.
[16] C. Zalarua, M. Iovu, F. Zalaru, A. Meghea, M. Giurginca, and M. Plavetie, "Coordination Compounds of Cu(II) with Some Substituted 2-(3,5-Dimethyl-Pyrazol-1-Yl)-Methyl-Acetanilides as Ligands," J. Serbian Chem. Soc., vol. 72, no. 3, 2007.
[17] F. A. Hassan, "Synthesis and Biological Evaluation of 1,3,4-Thiadiazole Derivative on Some Parameters of Immunity and Liver Enzymes," Res. J. Appl. Sci., vol. 6, pp. 7-12, 2011.
[18] E. Oruc, S. Rollas, F. Kandemirili, N. Shvets, and D. Dimoglo, "1,3,4-Thiadiazole Derivatives: Synthesis, Structure Elucidation and Structure Antituberculosis Activity Relationship Investigation," J. Med. Chem., vol. 47, pp. 6760-6767, 2004.
[19] Y. Karagozoglu, S. Turkoglu, A. E. Parlak, and N. O. Alayunt, "The Effects of Hydroxyurea Derivative 1,3,4-Thiadiazoles on Serum Biochemical Parameters and Antioxidant Status in Liver of Rats," Dig. J. Nanomater. Biostruct., vol. 8, no. 1, 2013.
[20] S. J. Gilani, S. A. Khan, and N. Siddiqui, "Synthesis and Pharmacological Evaluation of Condensed Heterocyclic 6-Substituted 1,2,4-Triazolo-[3,4-b]-1,3,4-Thiadiazole and 1,3,4-Oxadiazole Derivatives of Isoniazid," Bioorg. Med. Chem. Lett., vol. 20, no. 16, pp. 4762-476
Published
2024-05-28
How to Cite
Anatheil, A. H., Gatea, A. H., & Abdulredha, W. S. (2024). New Thiadiazole Derivative Shows Promising Bioactivity with Transition Metals in Rats. Central Asian Journal of Medical and Natural Science, 5(3), 406-414. Retrieved from https://www.cajmns.centralasianstudies.org/index.php/CAJMNS/article/view/2458
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Copyright (c) 2024 Amal Hussein Anatheil, Azhar Hameed Gatea, Wafa S. Abdulredha.
This work is licensed under a Creative Commons Attribution 4.0 International License.
