Evaluation of Torch Infections and Specific Humoral Responses Against HSV in Patients with Nonsegmental Vitiligo
Abstract
The aim of this study was to assess the TORCH infections and specific humoral responses against HSV in patients with nonsegmental vitiligo. The research consist of 18 to 60 years old 46 patients with nonsegmental vitiligo and 25 healthy individuals were enrolled. General clinico-laboratory results collected from all participants which CBC, biochemical analysis, specific skin test for depigmented patches-mexametria. ELISA was used for detection of IgG antibodies against TORCH infections (cytomegalovirus, herpes simplex viruses (HSV), rubella, toxoplasma gondii, chlamydia trachomatis) in sera of participants. HSV were detected from the sera of 31% of the patients and 12% of the controls. There was no significant difference between TORCH infections in patients and controls (???? > 0.05). HSV was detected from the sera of 23% of the patients and 6% of the controls (???? > 0.05). There were no significant differences between serum levels of IgM and IgA in patients and controls (???? > 0.05). Serum level of IgG was significantly lower in patients than in controls (???? > 0.05). Type of TORCH infections can change in patients with nonsegmental vitiligo. In addition, these patients have abnormalities in the production of antibodies against HSV that may have a role in the pathogenesis of nonsegmental vitiligo.
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