Assessment of the Role of Genetic Polymorphism of the Hemostatic System Factors of the F3 Gene in the Development of Thrombophilia in Women of the Uzbek Population

Abstract

The article presents the results of molecular genetic studies of the hemostasis gene G/T gene F3 in women with unsuccessful IVF who have thrombophilia in the Uzbek population living. Analysis of molecular genetic studies of the frequency distribution of alleles of the G/T polymorphism of the F3 gene in a sample of women from the main group showed that the functional G allele was determined in 72.7%, and in the group of control individuals without thrombophilia - in 100%, respectively. (χ2=10.65; p<0.001; OR=0.04; 95%CI 0.00 – 0.73). While the mutant allele “T” in the main group was detected in 49 chromosomes (49/180), which accounted for 37.4% of cases. (χ2=10.65; p<0.001; OR=22.96; 95%CI 1.38 – 382.75). Clinical molecular genetic studies indicate that patients with identified non-functional genotypes G/T of the F3 gene are at risk of developing severe thrombophilia, which amounted to 38.8% of cases. (χ2=11.67; p<0.003; OR=19.83; 95% CI1.15 – 341.95). Variants of polymorphisms of hetero-G/T and homozygous genotypes T/T of the F3 gene are significant prognostic criteria for the risk of developing undeveloped pregnancies in women with thrombophilia among women of the Uzbek population.