Evaluation of Some Immunological Aspects of Women with Polycystic Ovary Syndrome in Wasit Governorate

Miead khadheir Zaghir; Dr. Nisreen Habib  Al-Moussawil

Miead khadheir Zaghir Department of Biology –College of Education for pure Sciences-University of Wasit –Iraq
Dr. Nisreen Habib Al-Moussawil Department of Biology –College of Education for pure Sciences-University of Wasit –Iraq

Keywords: polycystic ovary syndrome, Interleukin-15, Interleukin IL6

Abstract

The aim of the study the Study immune linkage for the occurrence of cysts and Analyzing the results statistically to determine the extent of the immunological causes of the occurrence of polycysticovaries.Polycystic ovary syndrome (PCOS) is one of the commonest endocrine disorders affecting many females in reproductive period which start from menarche till the menopause and commonly caused infertility around the world, and is characterized by irregular menstrual cycle, Hyperandrogensim and polycystic ovary; it can be considered a conditions involving reproductive, metabolic and cardiovascular components leading to lifelong health implication. Its prevalence among infertile women is between (15% to 20%). There is evidence that PCOS is a pro inflammatory disorder, characterized by the presence of low grade chronic inflammation that correlated with obesity or insulin resistance (IR). The present study aims to determine the role of immunological and physiological response in the pathogenesis of PCOS. The current study included 100 females diagnosed with PCOS, there were recruited from Kamal Al-kut hospital in Wasit during November 2022 until January 2023 , the diagnosis of polycystic ovary syndrome was based on the Rotterdam 2003 criteria. The control group consists of 50 fertile women who have regular menstrual cycle with no sign of hyperandrogenism and subjected to ultrasound examination and have normal hormonal levels. The age was identical in both groups and it was between (20-40) years.

The present study was carried out in two parts: immunological study. ELISA technique has been used to determine the serum level of Interlukine-15and IL6.

The results of immunological study demonstrated that IL-15 andIL6 serum level were significantly increased (p<0.005)in pcos patients in comparison to control group. The mean level of that interleukin in patients and control group were (33.991±.57) pg/mL and (36.041±.03) and IL6 (85.944±.29), (84.24±6.39) pg/mL respectively.

Conclusions: In patients with pcos, The plasma level of IL-15, IL-6 is a major independent inflammatory predictor. Also, a ncrease in this hormone levels is an important indicator in predicting polycystic ovary syndrome.

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