Evaluating of Some Biochemical and Immunological Parameters in Patients with Myocardial Infarction

Hashim Hussein Hadi; Dr. Nisreen Habib  Al-Moussawi

Hashim Hussein Hadi Department of Biology –College of Education for pure Sciences-University of Wasit –Iraq
Dr. Nisreen Habib Al-Moussawi Department of Biology –College of Education for pure Sciences-University of Wasit –Iraq

Keywords: Acute myocardial infarction, Interleukin-18, Interleukin IL-1α

Abstract

The aim of the study was to evaluate some biochemical (CRP , Albumin )and immunological parameters in patients with myocardial infarction Myocardial infarction (MI) is a major cause of death and disability worldwideA heart attack, also known as myocardial infarction, occurs when blood flow to a section of the heart is cut off, resulting in the death of heart cells. This usually happens when a coronary artery becomes blocked due to the rupture of a vulnerable plaque made up of cholesterol, fatty acids, and white blood cells.

The study took place in the cardiac resuscitation unit at Al-Zahra Teaching Hospital and Al- Karama Teaching Hospital in Wasit Governorate from November 2022 to January 2023. Its objective was to examine the significance of physiological, immunological indicators, and inflammatory biomarkers for accurately diagnosing, assessing risk, and predicting the future outcomes of patients with acute myocardial infarction.

The study included 100 patients with acute myocardial infarction, including 71 men aged30- 70 years, and 29 women aged 33-75 years. And 50 samples from the control, 28 samples from men and 22 samples from women, and they were divided into three age groups. The first group is 30-45 years old, the second group is 46-60 years old, and the third group is 61-75 years old. Taking into account the risk factors for acute myocardial infarction, which include Sex, age, high blood pressure, diabetes, smoking, and dyslexia. Lipid lipids through a questionnaire.

This study also indicated, significant increase in the value of C-reactive protein and decrease in albumin levels. The current study on the study of interleukins (interleukin 18 and interleukin alpha 1) revealed a significant increase in the concentrations of these interleukins at p ≤ 0.05.

Conclusions: In patients with AMI, The plasma level of IL-18, IL-1α and CRP is a major independent inflammatory predictor. Also, a decrease in albumin levels is an important indicator in predicting myocardial infarction.

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