Evaluation of Adiponectin and IL6 in Patients with Diabetes Mellitus Type Two
Keywords:
interleukin-6, Adiponectin, diabetes mellitus
Abstract
e most prevalent kind of chronic metabolic illness, Type 2 diabetes is defined as by hyperglycemia (excessive blood glucose) brought on by a problem with protein, lipid, and carbohydrate metabolism. Adiponectin is adipokine produced by adipocytes××, is a well -known homeostatics factor for maintaining glucose amounts in the blood, Lipoprotein metabolism, and insulin resistance due to its anti-inflammatory×, anti -fibrotic, and anti oxidant properties. The adiponectin receptors dipoR1 and AdipoR2 mediate each of these metabolic processes. Additionally, One of the proteins with the greatest plasma concentrations is adiponectin. Adiponectin levels rise as a result of calorie restriction or weight loss, and this rise is linked to improved insulin sensitivity. Cytokines have a significant role in the selective death of beta cells that produce insulin and the impairment of insulin signaling.. Thus, An immune-mediated condition can be used to describe the second kind of diabetes. This study sought to determine the adiponectin and (IL-6) levels in type 2 diabetic patients in the region of Babil in Iraq.
References
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2. Preeti N. Malani, MD, MSJ, M., 2012. Harrison ’ s Principles of Internal Medicine. JAMA., 308(17), pp.1813–1814.
3. AL, O., et al. "Insulin Structure, Function and Diabetes Models in Animals." Journal of Experimental and Basic Medical Sciences 1.3 (2020): 96-101.
4. Huising, Mark O. "Paracrine regulation of insulin secretion." Diabetologia 63.10 (2020): 2057-2063.
5. Chen, J. et al., 2006. Secretion of adiponectin by human placenta: Differential modulation of adiponectin and its receptors by cytokines. Diabetologia, 49(6), pp.1292–1302.
6. Coppola, A. et al., 2010. Effect of weight loss on coronary circulation and adiponectin levels in obese women . , 134(3).
7. Ellingsgaard H, Hauselmann I, Schuler B, et al. Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. Nat Med 2011;17:1481–1489
8. Glund S, Krook A. Role of interleukin-6 signalling in glucose and lipid metabolism. Acta Physiol (Oxf) 2008;192:37–48
9. DeFronzo, Ralph A., et al. "Type 2 diabetes mellitus." Nature reviews Disease primers 1.1 (2015): 1-22.
10. Huising, Mark O. "Paracrine regulation of insulin secretion." Diabetologia 63.10 (2020): 2057-2063.
11. BOMMER, C., HEESEMANN, E., SAGALOVA, V., et al. 2017. The global economic burden of diabetes in adults aged 20-79 years: a cost-of-illness study. Lancet Diabetes Endocrinol, 5, 423-430.
12. SIRBU, A. E., BUBURUZAN, L., KEVORKIAN, S., MARTIN, S., BARBU, C., COPAESCU, C., SMEU, B. & FICA, S. 2018. Adiponectin expression in visceral adiposity is an important determinant of insulin resistance in morbid obesity. Endokrynol Pol.
13. HECHT BALDAUFF, N., TFAYLI, H., DONG, W., et al. 2016. Relationship of adiponectin and leptin with autoimmunity in children with new-onset type 1 diabetes: a pilot study. Pediatr Diabetes, 17, 249-56.
14. IWATA, M., HARA, K., KAMURA, Y., et al. 2018. Ratio of low molecular weight serum adiponectin to the total adiponectin value is associated with type 2 diabetes through its relation to increasing insulin resistance. PLoS One, 13, e0192609.
15. FUKUDA, S., KITA, S., OBATA, Y., et al. 2017. The unique prodomain of T-cadherin plays a key role in adiponectin binding with the essential extracellular cadherin repeats 1 and 2. J Biol Chem, 292, 7840-7849.
16. Ayelign, B., Negash, M., Andualem, H., Wondemagegn, T., Kassa, E., Shibabaw, T., ... & Molla, M. D. (2021). Association of IL-10 (− 1082 A/G) and IL-6 (− 174 G/C) gene polymorphism with type 2 diabetes mellitus in Ethiopia population. BMC Endocrine Disorders, 21, 1-8.
17. Ferrucci, L., & Fabbri, E. (2018). Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty. Nature Reviews Cardiology, 15(9), 505-522.
18. Hassan, A. J. (2015). Study The Relationship of IL-33 with Adiponectin in Postmenopausal Female with and without Type 2 Diabetes Mellitus. Medical Journal of Babylon, 12(3), 618-624.
19. Al-zubaidi, H. A. (2013). Serum Level of Adiponectin as a Risk Marker for Cardiovascular and Type 2 Diabetes Mellitus Patients. Medical Journal of Babylon, 10(2).
20. Rehman, K., Akash, M. S. H., Liaqat, A., Kamal, S., Qadir, M. I., & Rasul, A. (2017). Role of interleukin-6 in development of insulin resistance and type 2 diabetes mellitus. Critical Reviews™ in Eukaryotic Gene Expression, 27(3).
21. Diwan, A. G., Kuvalekar, A. A., Dharamsi, S., Vora, A. M., Nikam, V. A., & Ghadge, A. A. (2018). Correlation of serum adiponectin and leptin levels in obesity and type 2 diabetes mellitus. Indian journal of endocrinology and metabolism, 22(1), 93.
22. Prates, R. E., Beretta, M. V., Nascimento, F. V., Bernaud, F. R., de Almeira, J. C., & Rodrigues, T. C. (2016). Saturated fatty acid intake decreases serum adiponectin levels in subjects with type 1 diabetes. diabetes research and clinical practice, 116, 205-211
23. Toth, P. P., Barter, P. J., Rosenson, R. S., Boden, W. E., Chapman, M. J., Cuchel, M., ... & Rader, D. J. (2013). High-density lipoproteins: a consensus statement from the National Lipid Association. Journal of clinical lipidology, 7(5), 484-525.
24. Giardullo, L., Corrado, A., Maruotti, N., Cici, D., Mansueto, N., & Cantatore, F. P. (2021). Adipokine role in physiopathology of inflammatory and degenerative musculoskeletal diseases. International Journal of Immunopathology and Pharmacology, 35, 20587384211015034.
Published
2023-08-05
How to Cite
Farman, D. H. A., & Naji, R. R. (2023). Evaluation of Adiponectin and IL6 in Patients with Diabetes Mellitus Type Two. Central Asian Journal of Medical and Natural Science, 4(4), 311-317. Retrieved from https://www.cajmns.centralasianstudies.org/index.php/CAJMNS/article/view/1702
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Articles
