Role of Selected Vitamins in Women with Polycystic Ovarian Syndrome -Thi-Qar Governorate –Iraq
Keywords:
Polycystic ovarian syndrome, Vitamin A, Vitamin B6, Vitamin D3, Vitamin E
Abstract
Background: The enigma surrounding PCOS makes it a convoluted and multifarious condition. To tackle it, doctors usually prescribe a variation of lifestyle changes, including exercise, eating modifications, and vitamin/mineral intakes. It looks like Vitamin D has an eminent role in shaping the ovaries' follicle development. Plus, Vitamin B can diminish inflammation by degrading homocysteine as well as apparently limiting fertility chances and doubling the risk of miscarriages. Vitamin A is a must-have for sight, plus it's good for the reproductive system. Vitamin E helps shut down oxidation and keep physiological systems in check– both of which are key for reproductivity...
Objectives: Assessment the level of vitamin D3, B6, A, and vitamin E among studied groups.
Materials and Methods: We studied a big group from July 2021 to August 2022. This was split between a case group of 60 women with PCOS and a control group of 60 healthy reproductive-types. We took place at Bint Al-Huda Hospital in Nasiriya City, Thi-Qar governorate, plus one private gynecologist clinic. To get answers, we checked what vitamins were floating around their bodies and analyzed the data with heavy statistical testing.
Results: Often, the bodies of women with PCOS are bigger than fertile women. And, when it comes to pregnancy, there's a notable decrease among those with PCOS. We made sure to look into other variables too– like age, vitamin D3 levels, vitamin B6 levels, and vitamin A levels. But these factors were all the same regardless of PCOS status. The only exception was vitamin E... which actually showed up in higher concentrations for those with PCOS...
Conclusions: Regarding the vitamins D3, B6, and A, this recent study reveals no significant variations. However, intriguingly, there are notable disparities found in the case of vitamin E.
References
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25. Wood JR, Ho CKM, Nelson-Degrave VL, McAllister JM, Strauss JF. The molecular signature of polycystic ovary syndrome (PCOS) theca cells defined by gene expression profiling. J Reprod Immunol 2004; 63: 51-60.
26. GhazaleTefagh1 , Moloud Payab2,10*, Mostafa Qorbani3 , Farshad Sharif4 , Yasaman Sharif2 , Mahbubeh Sadat Ebrahimnegad Shirvani5 , Farzad Pourghazi2 , RashaAtlasi6 , Zhaleh Shadman4 , Nafseh Rezaei7,8, Erfan Mohammadi Vajari9 , Bagher Larijani2 & Mahbube Ebrahimpur4,10.Effect of vitamin E supplementation on cardiometabolic risk factors, infammatory and oxidative markers and hormonal functions in PCOS (polycystic ovary syndrome): a systematic review and meta‐analysis. Received: 24 July 2021; Accepted: 16 March 2022
27. Izadi A, Ebrahimi S, Shirzai S, Taghizadeh S, Parized M, Farzadi L, et al. Hormonal and metabolic effects of coenzyme q10 and/or vitamin E in patients with polycystic ovary syndrome. J Clin Endocrinol Metab. 2018. [PubMed] [Google Scholar]
28. Ebrahimi FA, Samimi M, Foroozanfard F, Jamilian M, Akbari H, Rahmani E, et al. The Effects of Omega-3 Fatty Acids and Vitamin E Co-Supplementation on Indices of Insulin Resistance and Hormonal Parameters in Patients with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Exp Clin Endocrinol Diabetes. 2017;125:353–9. [PubMed] [Google Scholar]
29. Gagne A, Wei SQ, Fraser WD, Julien P. Absorption, transport, and bioavailability of vitamin e and its role in pregnant women. J Obstet Gynaecol Can. 2009;31(3):210–7.
30. Hubalek M, Buchner H, Mortl MG, Schlembach D, Huppertz B, Firulovic B, Kohler W, Hafner E, Dieplinger B, Wildt L, et al. The vitamin E-binding protein afamin increases in maternal serum during pregnancy. Clin Chim Acta. 2014;434:41–7.
31. Dattilo M, Cornet D, Amar E, Cohen M, Menezo Y. The importance of the one carbon cycle nutritional support in human male fertility: a preliminary clinical report. Reprod Biol Endocrinol. 2014;12:71.
2. Elif Gunalan ,Aylin Yaba,and Bayram Yilmaz .The effect of nutrient supplementation in the management of polycystic ovary syndrome-associated metabolic dysfunction :A clinical review :2018 Dec:19(4):220-232.Published online 2018 Nov 15 .doi:10.4274/jtgga.2018.0077
3. Ming-Wei Lin1 and Meng-Hsing Wu2,* The role of vitamin D in polycystic ovary syndrome: India Journal of Medical Research; 2015 Sep;142(3):238-240. doi: 10.4103/0971-5916.166527
4. Tag, S., Sarandöl, E., & Dirican, M. Vitamin B6 supplementation improves oxidative stress and enhances serum paraoxonase/arylesterase activities in streptozotocin-induced diabetic rats. The Scientific World Journal;2014, 7,351598.
5. Cetin, I., Berti, C., & Calabrese, S. . Role of micronutrients in the periconceptional period. Human reproduction update,2010: 16(1), 80-95.
6. Agarwal, A., Aponte-Mellado, A., Premkumar, B. J., Shaman, A., & Gupta, S. . The effects of oxidative stress on female reproduction: a review. Reproductive biology and endocrinology:2012; 10(1), 1-31.
7. Kaul S, Zadeh AA, Shah PK. Homocysteine hypothesis for atherothrombotic cardiovascular disease: not validated. J Am Coll Cardiol. 2006;48(5):91423. https://doi.org/10.1016/j.jacc.2006.04.086
8. Yarali H, Yildirir A, Aybar F, Kabakci G, Bükülmez O, Akgül E, et al. Diastolic dysfunction and increased serum homocysteine concentrations may contribute to increased cardiovascular risk in patients with polycystic ovary syndrome. Fertil Steril. 2001;76:511–6. [PubMed] [Google Scholar]
9. Pu Y, Wang Z, Bian Y, Zhang F, Yang P, Li Y, et al. All-trans retinoic acid improves goat oocyte nuclear maturation and reduces apoptotic cumulus cells during in vitro maturation. Anim Sci J. 2014;85:833–9. [PubMed] [Google Scholar]
10. Deb GK, Dey SR, Bang JI, Lee JG, Kong IK. 9-cis Retinoic acid inhibits cumulus cell apoptosis during the maturation of bovine cumulus-oocyte-complexes. J Anim Sci. 2012;90:1798–806. [PubMed] [Google Scholar]
11. Budani, M. C., & Tiboni, G. M. (2020). Effects of supplementation with natural antioxidants on oocytes and preimplantation embryos. Antioxidants, 9(7), 612.
12. Chen, J., Guo, Q., Pei, Y. H., Ren, Q. L., Chi, L., Hu, R. K., & Tan, Y. . Effect of a short-term vitamin E supplementation on oxidative stress in infertile PCOS women under ovulation induction: a retrospective cohort study. BMC women's health,2020; 20(1), 1-9
13. Cicek N, Eryilmaz OG, Sarikaya E, Gulerman C, Genc Y. Vitamin E effect on controlled ovarian stimulation of unexplained infertile women. J Assist Reprod Genet. 2012; 29:325–8. [PMC free article] [PubMed] [Google Scholar]
14. Iris Holzer, John Preston Parry, Klara Beitl , Boban Pozderovic,Rodring Marculescu,and Johannes Ott. Parameters for Calcium Metabolism in Women with Polycystic Ovary Syndrome Who Undergo Stimulation with Letrozole: A Prospective Cohort Study. J. Clin. Med. 2022, 11(9), 2597; https://doi.org/10.3390/jcm11092597
15. Mahmoudi, T.; Gourabi, H.; Ashrafi, M.; Yazdi, R.S.; Ezabadi, Z. Calciotropic hormones, insulin resistance, and the polycystic ovary syndrome. Fertil. Steril. 2010, 93, 1208–1214. [Google Scholar] [CrossRef] [PubMed]
16. Krul-Poel, Y.H.M.; Koenders, P.P.; Steegers-Theunissen, R.P.; Ten Boekel, E.; Wee, M.M.T.; Louwers, Y.; Lips, P.; Laven, J.S.E.; Simsek, S. Vitamin D and metabolic disturbances in polycystic ovary syndrome (PCOS): A cross-sectional study. PLoS ONE 2018, 13, e0204748. [Google Scholar] [CrossRef] [PubMed]
17. Moridi, I.; Chen, A.; Tal, O.; Tal, R. The Association between Vitamin D and Anti-Mullerian Hormone: A Systematic Review and Meta-Analysis. Nutrients 2020, 12, 1567. [Google Scholar] [CrossRef]
18. Karadag, C.; Yoldemir, T.; Yavuz, D.G. Effects of vitamin D supplementation on insulin sensitivity and androgen levels in vitamin-D-deficient polycystic ovary syndrome patients. J. Obstet. Gynaecol. Res. 2018, 44, 270–277. [Google Scholar] [CrossRef] [PubMed]
19. Mehmet Kulhan, Nur Gozde Kulhan, Umit Arslan Nayki, Nahit Ata, Pasa Ulug,and Cuma Mertoglu. Assessment of the relationship between serum vitamin (A, B12, C, D, folate) and zinc levels and polycystic ovary syndrome; Arch Med Sci Civil Dis 2017; 2: e62–e69. DOI: https://doi.org/10.5114/amscd.2017.66840 Online publish date: 2017/03/27
20. National Institutes of Health. (2018). Vitamin B6. National Institutes of Health. Available online: https://ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/
21. Bendich, A. ; The potential for dietary supplements to reduce premenstrual syndrome (PMS) symptoms.2000; J Am Coll Nutr. 19: 3-12.
22. Vitamin B6: Sources & Benefits. Live Science.2020; Avaliable Online: https://www.livescience.com/51920-vitamin-b6.html
23. Loverro G, Lorusso F, Mei L, Depalo R, Cormio G, Selvaggi L. The plasma homocysteine levels are increased in polycystic ovary syndrome. Gynecol Obstet Invest. 2002;53:157–62. [PubMed] [Google Scholar]
24. Badawy A, State O, El Gawad S, El Aziz OA. Plasma homocysteine and polycystic ovary syndrome: the missed link. Eur J Obstet Gynecol Reprod Biol. 2007;131:68–72. [PubMed] [Google Scholar]
25. Wood JR, Ho CKM, Nelson-Degrave VL, McAllister JM, Strauss JF. The molecular signature of polycystic ovary syndrome (PCOS) theca cells defined by gene expression profiling. J Reprod Immunol 2004; 63: 51-60.
26. GhazaleTefagh1 , Moloud Payab2,10*, Mostafa Qorbani3 , Farshad Sharif4 , Yasaman Sharif2 , Mahbubeh Sadat Ebrahimnegad Shirvani5 , Farzad Pourghazi2 , RashaAtlasi6 , Zhaleh Shadman4 , Nafseh Rezaei7,8, Erfan Mohammadi Vajari9 , Bagher Larijani2 & Mahbube Ebrahimpur4,10.Effect of vitamin E supplementation on cardiometabolic risk factors, infammatory and oxidative markers and hormonal functions in PCOS (polycystic ovary syndrome): a systematic review and meta‐analysis. Received: 24 July 2021; Accepted: 16 March 2022
27. Izadi A, Ebrahimi S, Shirzai S, Taghizadeh S, Parized M, Farzadi L, et al. Hormonal and metabolic effects of coenzyme q10 and/or vitamin E in patients with polycystic ovary syndrome. J Clin Endocrinol Metab. 2018. [PubMed] [Google Scholar]
28. Ebrahimi FA, Samimi M, Foroozanfard F, Jamilian M, Akbari H, Rahmani E, et al. The Effects of Omega-3 Fatty Acids and Vitamin E Co-Supplementation on Indices of Insulin Resistance and Hormonal Parameters in Patients with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Exp Clin Endocrinol Diabetes. 2017;125:353–9. [PubMed] [Google Scholar]
29. Gagne A, Wei SQ, Fraser WD, Julien P. Absorption, transport, and bioavailability of vitamin e and its role in pregnant women. J Obstet Gynaecol Can. 2009;31(3):210–7.
30. Hubalek M, Buchner H, Mortl MG, Schlembach D, Huppertz B, Firulovic B, Kohler W, Hafner E, Dieplinger B, Wildt L, et al. The vitamin E-binding protein afamin increases in maternal serum during pregnancy. Clin Chim Acta. 2014;434:41–7.
31. Dattilo M, Cornet D, Amar E, Cohen M, Menezo Y. The importance of the one carbon cycle nutritional support in human male fertility: a preliminary clinical report. Reprod Biol Endocrinol. 2014;12:71.
Published
2023-08-05
How to Cite
Ali, I. N., & Hussein, R. A. (2023). Role of Selected Vitamins in Women with Polycystic Ovarian Syndrome -Thi-Qar Governorate –Iraq. Central Asian Journal of Medical and Natural Science, 4(4), 257-263. Retrieved from https://www.cajmns.centralasianstudies.org/index.php/CAJMNS/article/view/1695
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Articles
