Neurosteroids and Addictive Pathology
Keywords:
dehydroepiandrosterone sulphate, androstenedione and pregnenolone, allopregnanolone and tetrahydro-deoxycorticosterone
Abstract
Biochemical, physiological and pharmacological aspects of hormonal regulation by endogenous chemical compounds of steroid structure have been well known for several decades. First and foremost, these are steroid hormones of the glucocorticoid group, which are the main chemical effector of stress and, thanks to the work of Sellier and his followers, are considered to be one of the key links in the pathogenesis of a wide range of diseases. Steroids originating in the central and peripheral nervous system have been discovered and intensively studied during the past 15 years. They have a different spectrum of biological activity and, in contrast to hormones, which have a discrete action, these substances, termed neurosteroids (NS), interact with targets located near the site of their synthesis.
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3. Khamdamov B.Z. Indicators of immunocitocine status in purulent-necrotic lesions of the lover extremities in patients with diabetes mellitus.//American Journal of Medicine and Medical Sciences, 2020 10(7) 473-478.
4. M. I. Kamalova, N.K.Khaidarov, Sh.E.Islamov,Pathomorphological Features of hemorrhagic brain strokes, Journal of Biomedicine and Practice 2020, Special issue, pp. 101-105
5. Kamalova Мalika Ilkhomovna, Islamov Shavkat Eriyigitovich, Khaidarov Nodir Kadyrovich. Morphological Features Of Microvascular Tissue Of The Brain At Hemorrhagic Stroke. The American Journal of Medical Sciences and Pharmaceutical Research, 2020. 2(10), 53-59
6. Khodjieva D. T., Khaydarova D. K., Khaydarov N. K. Complex evaluation of clinical and instrumental data for justification of optive treatment activites in patients with resistant forms of epilepsy. American Journal of Research. USA. № 11-12, 2018. C.186-193.
7. Khodjieva D. T., Khaydarova D. K. Clinical and neuroph clinical and neurophysiological ch ogical characteristics of teristics of post-insular cognitive disorders and issues of therapy optimization. Central Asian Journal of Pediatrics. Dec.2019. P 82-86
8. Kasimov, Arslanbek; Abdullaeva, Nargiza; Djurabekova, Aziza; Shomurodova, Dilnoza//Features of diagnosis and clinic of post-traumatic epilepsy against the background of concomitant somatic diseases. International Journal of Pharmaceutical Research (09752366) . Jul-Sep2020, Vol. 12 Issue 3, p1788-1792. 5p.
9. Kasimov Arslanbek Atabaevich, Bozorova Sabohat Normo’min qizi, & Gulkhayo Eshmatovna Zhumanova. (2022). Results of a study of clinical and neurophysiological changes in patients with post-traumatic epilepsy with concomitant somatic diseases on the basis of complex drug therapy. World bulletin of public health 10, 186-190
10. Kasimov Arslanbek Atabaevich. (2022). Dynamics of clinical and neurophysiological changes against the background of complex medical therapy in patients with posttraumatic epilepsy with concomitant somatic diseases. Frontline Medical Sciences and Pharmaceutical Journal, 2(03), 78–87.
11. Khudaynazarova Muattar Tokhirjonovna, Ruziyev Jononbek Elmurodovich, & Kasimov Arslanbek Atabayevich. (2022). Peculiarities of diagnosis and clinical picture of posttraumatic epilepsy against the background of concomitant somatic diseases. World bulletin of public health, 10, 121-126.
12. Uralov, F. S. ., Khurramov, M. B. ., Kasimov, A. A. ., & Mamurova, M. M. . (2022). Modern Methods of Epilepsy Treatment and Prevention of Tactical and Therapeutic Errors in Epilepsy Treatment. International Journal Of Health Systems And Medical Sciences, 1(4), 374–377.
13. Шомуродова Д. С., Джурабекова А. Т., Мамурова М. М. Особенности и прогноз поражения нервной системы у беременных женщин с преэклампсией характеризуемые методами функциональной диагностики //журнал неврологии и нейрохирургических исследований. – 2020. – Т. 1. – №. 2.
14. Мамурова, М., Рузиева, Ш., Олланова, Ш., Хакимова, С., & Джурабекова, А. (2015). Клинико-неврологические особенности Хронических цереброваскулярных заболеваний, обусловленных Артериальной гипертензией, у пациентов молодого возраста. Журнал вестник врача, 1(4), 39–42.
15. Мамурова М. М., Джурабекова А. Т., Игамова С. С. Оценка когнитивных вызванных потенциалов головного мозга (р-300) у лиц молодого возраста с артериальной гипотензией //журнал неврологии и нейрохирургических исследований. – 2021. – Т. 2. – №. 1.
16. Rakhmonova H.N., Rakhmonov Z.M. Innervation Relationships of the Gallbladder Nerve Apparatus with Spinal and Rheumatic Nerve Ganglia (Literature Review). Eurasian Medical Research Periodical, 18, 105-108.
17. Рузиева, Ш., Мамурова, М., Хакимова, С., & Джурабекова, А. (2016). Клиническая характеристика больных с транзиторными ишемическими атаками. Журнал проблемы биологии и медицины, (2 (87), 79–82.
Published
2023-06-30
How to Cite
N, A. N., A., K. A., L., T. K., & Sh., T. F. (2023). Neurosteroids and Addictive Pathology. Central Asian Journal of Medical and Natural Science, 4(3), 1189-1194. Retrieved from https://www.cajmns.centralasianstudies.org/index.php/CAJMNS/article/view/1653
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